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Iron handling by the human kidney: Glomerular filtration and tubular reabsorption both contribute to urinary iron excretionvan Raaij SE, Rennings AJ, Biemond BJ, Schols SE, Wiegerinck ET, Roelofs HM, Hoorn EJ, Walsh SB, Nijenhuis T, Swinkels DW, Van Swelm R. Am J Physiol Renal Physiol 2019;Epub.
Provisional standardization of hepcidin assays: creating a traceability chain with a primary reference material, candidate reference method and a commutable secondary reference materialDiepeveen, Laarakkers, Martos, Pawlak, Uğuz, Verberne, van Swelm, Klaver, de Haan, Pitts, Bansal, Abbas, Fillet, Lefebvre, Geurts-Moespot, Girelli, Castagna, Herkert, Itkonen, Olbina, Tomosugi, Westerman, Delatour, Weykamp, Swinkels. CCLM 2018; Epub
Inhibition of Nrf2 alters cell stress induced by chronic iron exposure in human proximal tubular epithelial cellsvan Raaij SEG, Masereeuw R, Swinkels DW, van Swelm RPL. Toxicol Lett 2018;295:179.
Tubular iron deposition and iron handling proteins in human healthy kidney and chronic kidney diseasevan Raaij S, van Swelm R, Bouman K, Cliteur M, van den Heuvel M, Pertijs J, Patel D, Bass P, van Goor H, Unwin R, Srai SK, Swinkels D. Scientific Reports 2018;8(1):9353.
Labile plasma iron levels predict survival in patients with lower-risk myelodysplastic syndromesde Swart, Reiniers, Bagguley, van Marrewijk, Bowen, Hellström-Lindberg, Tatic, Symeonidis, Huls, Cermak, van de Loosdrecht, Garelius, Culligan, Macheta, Spanoudakis, Panagiotidis, Krejci, Blijlevens, Langemeijer, Droste, Swinkels, Smith, de Witte, EUMDS
Sustained plasma hepcidin suppression and iron elevation by Anticalin-derived hepcidin antagonist in cynomolgus monkeyHohlbaum AM, Gille H, Trentmann S, Kolodziejczyk M, Rattenstetter B, Laarakkers CM, Katzmann G, Christian HJ, Andersen N, Allersdorfer A, Olwill SA, Meibohm B, Audoly LP, Swinkels DW, van Swelm RPL. Br J Pharmacol 2018;175(7):1054-1065.
Endogenous hepcidin synthesis protects the distal nephron against hemin and hemoglobin mediated necroptosisvan Swelm RPL, Vos M, Verhoeven F, Thévenod F, Swinkels DW. Cell Death Dis 2018;9(5):550.
Iron absorption from oral iron supplements given on consecutive versus alternate days and as single morning doses versus twice-daily split dosing in iron-depleted women: two open-label, randomised controlled trialsStoffel NU, Cercamondi CI, Brittenham G, Zeder C, Geurts-Moespot AJ, Swinkels DW, Moretti D, Zimmermann MB. Lancet Haematol 2017;4(11):e524-e533.
Prediction of human iron bioavailability using rapid c-ELISAs for human plasma hepcidinStoffel NU, Zeder C, Fort E, Swinkels DW, Zimmermann MB, Moretti D. Clin Chem Lab Med 2017;55(8):1186-1192.
Interleukin-6 and Hepcidin Levels during Hormone-Deplete and Hormone-Replete Phases of an Oral Contraceptive Cycle: A Pilot StudySim M, Dawson B, Landers G, Swinkels DW, Wiegerinck E, Yeap BB, Trinder D, Peeling P. Ann Nutr Metab 201770(2):100-105.
Factors influencing the post-exercise hepcidin-25 response in elite athletesPeeling P, McKay AKA, Pyne DB, Guelfi KJ, McCormick RH, Laarakkers CM, Swinkels DW, Garvican-Lewis LA, Ross MLR, Sharma AP, Leckey JJ, Burke LM. Eur J Appl Physiol 2017;117(6):1233-1239.
Serum ferritin and risk for new-onset heart failure and cardiovascular events in the communityKlip IT, Voors AA, Swinkels DW, Bakker SJ, Kootstra-Ros JE, Lam CS, van der Harst P, van Veldhuisen DJ, van der Meer P. Eur J Haert Fail 2017; 19(3):348-356.
Dietary hemoglobin rescues young piglets from severe iron deficiency anemia: Duodenal expression profile of genes involved in heme iron absorption.Staroń R, Lipiński P, Lenartowicz M, Bednarz A, Gajowiak A, Smuda E, Krzeptowski W, Pieszka M, Korolonek T, Hamza I, Swinkels DW, Van Swelm RPL, Starzyński RR. PLoS ONE 2017; 12(7):e0181117.
Cardiac Hepcidin Expression Associates with Injury Independent of Iron.van Breda GF, Bongartz LG, Zhuang W, van Swelm RP, Pertijs J, Braam B, Cramer MJ, Swinkels DW, Doevendans PA, Verhaar MC, Masereeuw R, Joles JA, Gaillard CA. Am J Nephrol 2016;44(5):368-378.
Safety, pharmacokinetics and pharmacodynamics of the anti-hepcidin Spiegelmer lexaptepid pegol in healthy subjectsBoyce M, Warrington S, Cortezi B, Zöllner S, Vauléon S, Swinkels DW, Summo L, Schwoebel F, Riecke KBr J Pharmacol 2016. 173(10):1580-8
The donation interval of 56 days requires extension to 180 days for whole blood donors to recover from changes in iron metabolismSchotten N, Pasker-de Jong PC, Moretti D, Zimmermann M, Geurts-Moespot A, Swinkels DW, van Kraaij MG. Blood 2016. In press
Seven days of high carbohydrate ingestion does not attenuate post-exercise IL-6 and hepcidin levelsBadenhorst CE, Dawson B, Cox GR, Sim M, Laarakkers CM, Swinkels DW, Peeling P. Eur J Appl Physiol 2016. 116(9):1715-24
Hyperferritinemia and iron metabolism in Gaucher disease: Potential pathophysiological implicationsRegenboog M, van Kuilenburg AB, Verheij J, Swinkels DW, Hollak CE. Blood Rev 2016. In press
Live high, train low - influence on resting and post-exercise hepcidin levelsGovus AD, Peeling P, Abbiss CR, Lawler NG, Swinkels DW, Laarakkers CM, Thompson KG, Peiffer JJ, Gore CJ, Garvican-Lewis LA. Scand J Med Sci Sports 2016. In press
Iron Refractory Iron Deficiency Anemia (IRIDA): A heterogeneous disease that is not always iron refractoryDonker, Schaap, Novotny, Smeets, Peters, van den Heuvel, Raphael, Rijneveld, Appel, Vlot, Versluijs, van Gelder, Granzen, Janssen, Rennings, van de Veerdonk, Brons, Bakkeren, Nijziel, Vlasveld, Swinkels. Am J Hematol 2016. In press
Catalytic Iron and Acute Kidney InjuryLeaf DE, Swinkels DW. Am J Physiol Renal Physiol 2016; In press
Toward Worldwide Hepcidin Assay Harmonization: Identification of a Commutable Secondary Reference Material.van der Vorm LN, Hendriks, Laarakkers, Klaver, Armitage, Bamberg, Geurts-Moespot, Girelli, Herkert, Itkonen, Konrad, Tomosugi, Westerman, Bansal, Campostrini, Drakesmith, Fillet, Olbina, Pasricha, Pitts, Sloan, Tagliaro, Weykamp, Swinkels
Hepcidin in the diagnosis of iron disordersGirelli D, Nemeth E, Swinkels DW. Blood 2016;127(23):2809-13
Microbial metabolism shifts towards an adverse profile with supplementary iron in the TIM-2 In vitro model of the human colonKortman GA, Dutilh BE, Maathuis AJ, Engelke UF, Boekhorst J, Keegan KP, Nielsen FG, Betley J, Weir JC, Kingsbury Z, Kluijtmans LA, Swinkels DW, Venema K, Tjalsma H. Front Microbiol 2016;6:1481.
Renal handling of circulating and renal-synthesized hepcidin and its protective effects against hemoglobin-mediated kidney injuryvan Swelm RP, Wetzels JF, Verweij VG, Laarakkers CM, Pertijs JC, van der Wijst J, Thévenod F, Masereeuw R, Swinkels DW. J Am Soc Nephrol 2016; 27(9):2720-32.
Second international round robin for the quantification of serum non-transferrin-bound iron and labile plasma iron in patients with iron-overload disordersde Swart L, Hendriks JC, van der Vorm LN, Cabantchik ZI, Evans PJ, Hod EA, Brittenham GM, Furman Y, Wojczyk B, Janssen MC, Porter JB, Mattijssen VE, Biemond BJ, MacKenzie MA, Origa R, Galanello R, Hider RC, Swinkels DW. Haematologica 2016;101(1):38-45.
Iron management in chronic kidney disease: conclusions from a "Kidney Disease: Improving Global Outcomes" (KDIGO) Controversies ConferenceMacdougall IC, Bircher AJ, Eckardt KU, Obrador GT, Pollock CA, Stenvinkel P, Swinkels DW, Wanner C, Weiss G, Chertow GM; Conference Participants. Kidney Int 2016;89(1):28-39.
EMQN best practice guidelines for the molecular genetic diagnosis of hereditary hemochromatosis (HH)Porto G, Brissot P, Swinkels DW, Zoller H, Kamarainen O, Patton S, Alonso I, Morris M, Keeney S. Eur J Hum Genet 2016;24(4):479-95.
Course of iron parameters in HFE-hemochromatosis patients during initial treatment with erythrocytapheresis compared to phlebotomyRombout-Sestrienkova E, Koek GH, Neslo R, van Kraaij M, Menheere PP, Masclee A, Swinkels DW. J Clin Apher 2016 [Epub ahead of print].
Timing of post-exercise carbohydrate ingestion: influence on IL-6 and hepcidin responsesBadenhorst CE, Dawson B, Cox GR, Laarakkers CM Swinkels DW, Peeling P. Eur J Appl Physiol. 2015;115(10):2215-22
Oral contraception does not alter typical post-exercise interleukin-6 and hepcidin levels in femalesSim M, Dawson B, Landers G, Swinkels DW, Tjalsma H, Yeap BB, Trinder D, Peeling P. J Sci Med Sport. 2015;18(1):8-12.
Iron and hepcidin as risk factors in atherosclerosis: what do the genes say?Galesloot TE, Janss LL, Burgess S, Kiemeney LA, den Heijer M, de Graaf J, Holewijn S, Benyamin B, Whitfield JB, Swinkels DW, Vermeulen SH. BMC Genet 2015;16:79.
Oral iron supplements increase hepcidin and decrease iron absorption from daily or twice-daily doses in iron-depleted young womenMoretti D, Goede JS, Zeder C, Jiskra M, Chatzinakou V, Tjalsma H, Melse-Boonstra A, Brittenham G, Swinkels DW, Zimmermann MB. Blood 2015;126(17):1981-9.
Donation intensity and metabolic syndrome in active whole-blood donorsPeffer K, Verbeek AL, Swinkels DW, Geurts-Moespot AJ, den Heijer M, Atsma F. Vox Sang. 2015;109(1):25-34.
Acute dietary carbohydrate manipulation and the subsequent inflammatory and hepcidin responses to exerciseBadenhorst CE, Dawson B, Cox GR, Laarakkers CM, Swinkels DW, Peeling P. Eur J Appl Physiol. 2015;115(12):2521-30
The aetiology of anaemia during pregnancy: a study to evaluate the contribution of iron deficiency and common infections in pregnant Ugandan womenBaingana RK, Enyaru JK, Tjalsma H, Swinkels DW, Davidsson L. Public Health Nutr 2015;18(8):1423-35.
Iron fortification adversely affects the gut microbiome, increases pathogen abundance and induces intestinal inflammation in Kenyan infantsJaeggi T, Kortman GA, Moretti D, Chassard C, Holding P, Dostal A, Boekhorst J, Timmerman HM, Swinkels DW, Tjalsma H, Njenga J, Mwangi A, Kvalsvig J, Lacroix C, Zimmermann MB. Gut 2015;64(5):731-42.
Low dietary iron intake restrains the intestinal inflammatory response and pathology of enteric infection by food-borne bacterial pathogensKortman GA, Mulder ML, Richters TJ, Shanmugam NK, Trebicka E, Boekhorst J, Timmerman HM, Roelofs R, Wiegerinck ET, Laarakkers CM, Swinkels DW, Bolhuis A, Cherayil BJ, Tjalsma H. Eur J Immunol 2015;45(9):2553-67.
Hepcidin in chronic kidney disease: not an anaemia management tool, but promising as a cardiovascular biomarkervan der Weerd NC, Grooteman MP, Nubé MJ, ter Wee PM, Swinkels DW, Gaillard CA. Neth J Med 2015;73(3):108-18.
Underestimation of hepcidin concentration by time of flight mass spectrometry and competitive ELISA in hepcidin p.Gly71Asp heterozygotesvan der Vorm LN, van Meijel LJ, Lips J, Galesloot TE, Laarakkers CM, Swinkels DW. Clin Chem Lab Med 2015 [Epub ahead of print].
Correlates of hepcidin and NTBI according to HFE status in patients referred to a liver centreRyan E, Ryan JD, Russell J, Coughlan B, Tjalsma H, Swinkels DW, Stewart S, Crowe JP. Acta Haematol 2015;133(2):155-61.
Differences in the erythropoiesis-hepcidin-iron store axis between hemoglobin H disease and β-thalassemia intermediaOriga R, Cazzola M, Mereu E, Danjou F, Barella S, Giagu N, Galanello R, Swinkels DW. Haematologica 2015;100(5):e169-71.
Congenital sideroblastic anemia due to mutations in the mitochondrial HSP70 homologue HSPA9Schmitz-Abe K, Ciesielski SJ, Schmidt PJ, Campagna DR, Rahimov F, Schilke BA, Cuijpers M, Rieneck K, Lausen B, Linenberger ML, Sendamarai AK, Guo C, Hofmann I, Newburger PE, Matthews D, Shimamura A, Snijders PJ, Towne MC, Niemeyer CM, Watson HG, Dziegiel
The quality of hereditary haemochromatosis guidelines: a comparative analysisVanclooster A, Cassiman D, Van Steenbergen W, Swinkels DW, Janssen MC, Drenth JP, Aertgeerts B, Wollersheim H. Clin Res Hepatol Gastroenterol 2015;39(2):205-14.
Iron status and the acute post-exercise hepcidin response in athletesPeeling P, Sim M, Badenhorst CE, Dawson B, Govus AD, Abbiss CR, Swinkels DW, Trinder D. PLoS One. 2014;9(3):e93002.
Influence of post-exercise hypoxic exposure on hepcidin response in athletesBadenhorst CE, Dawson B, Goodman C, Sim M, Cox GR, Gore CJ, Tjalsma H, Swinkels DW, Peeling P. Eur J Appl Physiol. 2014;114(5):951-9.
A seven day running training period increases basal urinary hepcidin levels as compared to cyclingSim M, Dawson B, Landers GJ, Swinkels DW, Tjalsma H, Wiegerinck ET, Trinder D, Peeling P. J Int Soc Sports Nutr. 2014;11(1):14.
Serum hepcidin is associated with presence of plaque in postmenopausal women of a general populationGalesloot TE, Holewijn S, Kiemeney LA, de Graaf J, Vermeulen SH, Swinkels DW. Arterioscler Thromb Vasc Biol 2014;34(2):446-56.
The effect of iron loading and iron chelation on the innate immune response and subclinical organ injury during human endotoxemia: a randomized trialvan Eijk LT, Heemskerk S, van der Pluijm RW, van Wijk SM, Peters WH, van der Hoeven JG, Kox M, Swinkels DW, Pickkers P. Haematologica 2014;99(3):579-87.
Acute hypoxic exercise does not alter post-exercise iron metabolism in moderately trained endurance athletesGovus AD, Abbiss CR, Garvican-Lewis LA, Swinkels DW, Laarakkers CM, Gore CJ, Peeling P. Eur J Appl Physiol. 2014;114(10):2183-91
Practice guidelines for the diagnosis and management of microcytic anemias due to genetic disorders of iron metabolism or heme synthesisDonker AE, Raymakers RA, Vlasveld LT, van Barneveld T, Terink R, Dors N, Brons PP, Knoers NV, Swinkels DW. Blood. 2014;123(25):3873-86
Hematologic parameters predicting a response to oral iron therapy in chronic inflammationvan Santen S, de Mast Q, Oosting JD, van Ede A, Swinkels DW, van der Ven AJ. Haematologica 2014;99(9):e171-3.
Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosisBenyamin B, Esko T, Ried JS, Radhakrishnan A, Vermeulen SH, Traglia M, Gögele M, Anderson D, Broer L, Podmore C, Luan J, Kutalik Z, Sanna S, van der Meer P, Tanaka T, Wang F, Westra HJ, Franke L, Mihailov E, Milani L, Hälldin J, Winkelmann J, Meitinger T,
Conventional and novel peripheral blood iron markers compared against bone marrow in Malawian childrenJonker FA, Boele van Hensbroek M, Leenstra T, Vet RJ, Brabin BJ, Maseko N, Gushu MB, Emana M, Kraaijenhagen R, Tjalsma H, Swinkels DW, Calis JC. J Clin Pathol 2014;67(8):717-23.
Iron-induced virulence of Salmonella enterica serovar typhimurium at the intestinal epithelial interface can be suppressed by carvacrolKortman GA, Roelofs RW, Swinkels DW, de Jonge MI, Burt SA, Tjalsma H. Antimicrob Agents Chemother 2014;58(3):1664-70.
Nutritional iron turned inside out: intestinal stress from a gut microbial perspectiveKortman GA, Raffatellu M, Swinkels DW, Tjalsma H. FEMS Microbiol Rev 2014;38(6):1202-34.
Engineered human lipocalin as an antibody mimetic: application to analysis of the small peptide hormone hepcidinGrebenchtchikov N, Geurts-Moespot AJ, Trentmann S, Andersen N, Bel Aiba RS, Allersdorfer A, Laarakkers CM, Sweep FC, Tjalsma H, Hohlbaum AM, Swinkels DW. Clin Chem 2014;60(6):897-9.
The effect of iron loading and iron chelation on the innate immune response and subclinical organ injury during human endotoxemia: a randomized trialvan Eijk LT, Heemskerk S, van der Pluijm RW, van Wijk SM, Peters WH, van der Hoeven JG, Kox M, Swinkels DW, Pickkers P. Haematologica 2014;99(3):579-87.
X-linked sideroblastic anaemia due to ALAS₂ mutations in the Netherlands: a disease in disguiseDonker AE, Raymakers RA, Nieuwenhuis HK, Coenen MJ, Janssen MC, MacKenzie MA, Brons PP, Swinkels DW. Neth J Med 2014;72(4):210-7.
X-linked sideroblastic anemia due to ALAS2 intron 1 enhancer element GATA-binding site mutationsCampagna DR, de Bie CI, Schmitz-Abe K, Sweeney M, Sendamarai AK, Schmidt PJ, Heeney MM, Yntema HG, Kannengiesser C, Grandchamp B, Niemeyer CM, Knoers NV, Swart S, Marron G, van Wijk R, Raymakers RA, May A, Markianos K, Bottomley SS, Swinkels DW, Fleming M
The importance of the general practitioner as an information source for patients with hereditary haemochromatosisTeixeira E, Borlido-Santos J, Brissot P, Butzeck B, Courtois F, Evans RW, Fernau J, Nunes JA, Mullett M, Paneque M, Pineau B, Porto G, Sorrill R, Sanchez M, Swinkels DW, Toska K, Varkonyi J; EFAPH, the European Federation of Associations of Patients with
Effect of exercise modality and intensity on post-exercise interleukin-6 and hepcidin levelsSim M, Dawson B, Landers G, Swinkels DW, Tjalsma H, Trinder D, Peeling P. Int J Sport Nutr Exerc Metab. 2013;23(2):178-86.
Associations of common variants in HFE and TMPRSS6 with iron parameters are independent of serum hepcidin in a general population: a replication studyGalesloot TE, Geurts-Moespot AJ, den Heijer M, Sweep FC, Fleming RE, Kiemeney LA, Vermeulen SH, Swinkels DW. J Med Genet 2013;50(9):593-8.
The effect of frequent whole blood donation on ferritin, hepcidin, and subclinical atherosclerosisPeffer K, den Heijer M, Holewijn S, de Graaf J, Swinkels DW, Verbeek AL, Atsma F. Transfusion 2013;53(7):1468-74.
The iron link between malaria and invasive non-typhoid Salmonella infectionsvan Santen S, de Mast Q, Swinkels DW, van der Ven AJ. Trends Parasitol 2013;29(5):220-7.
Inverse relationship of serum hepcidin levels with CD4 cell counts in HIV-infected patients selected from an Indonesian prospective cohort studyWisaksana R, de Mast Q, Alisjahbana B, Jusuf H, Sudjana P, Indrati AR, Sumantri R, Swinkels D, van Crevel R, van der Ven A. PLoS One 2013;8(11):e79904.
Low hepcidin levels in severely anemic malawian children with high incidence of infectious diseases and bone marrow iron deficiencyJonker FA, Calis JC, Phiri K, Kraaijenhagen RJ, Brabin BJ, Faragher B, Wiegerinck ET, Tjalsma H, Swinkels DW, van Hensbroek MB. PLoS One 2013;8(12):e78964.
Hepcidin-25 is related to cardiovascular events in chronic haemodialysis patientsvan der Weerd NC, Grooteman MP, Bots ML, van den Dorpel MA, den Hoedt CH, Mazairac AH, Nubé MJ, Penne EL, Wetzels JF, Wiegerinck ET, Swinkels DW, Blankestijn PJ, Ter Wee PM; CONTRAST Investigators. Nephrol Dial Transplant. 2013;28(12):3062-71.
Tubular reabsorption and local production of urine hepcidin-25Peters HP, Laarakkers CM, Pickkers P, Masereeuw R, Boerman OC, Eek A, Cornelissen EA, Swinkels DW, Wetzels JF. BMC Nephrol. 2013;14:70.
Iron metabolism in the pathogenesis of iron-induced kidney injuryMartines AM, Masereeuw R, Tjalsma H, Hoenderop JG, Wetzels JF, Swinkels DW. Nat Rev Nephrol 2013;9(7):385-98.
Improved mass spectrometry assay for plasma hepcidin: detection and characterization of a novel hepcidin isoformLaarakkers CM, Wiegerinck ET, Klaver S, Kolodziejczyk M, Gille H, Hohlbaum AM, Tjalsma H, Swinkels DW. PLoS One 2013;8(10):e75518.
Non-transferrin-bound iron: a promising biomarker in iron overload disordersMaas RP, Voets PJ, de Swart L, Swinkels DW. Ned Tijdschr Geneeskd 2013;157(49):A6258.
Relevance of dietary iron intake and bioavailability in the management of HFE hemochromatosis: a systematic reviewMoretti D, van Doorn GM, Swinkels DW, Melse-Boonstra A. Am J Clin Nutr 2013;98(2):468-79.
The effects of carbohydrate ingestion during endurance running on post-exercise inflammation and hepcidin levelsSim M, Dawson B, Landers G, Wiegerinck ET, Swinkels DW, Townsend MA, Trinder D, Peeling P. Eur J Appl Physiol. 2012;112(5):1889-98.
Hepcidin-25 in chronic hemodialysis patients is related to residual kidney function and not to treatment with erythropoiesis stimulating agentsvan der Weerd NC, Grooteman MP, Bots ML, van den Dorpel MA, den Hoedt CH, Mazairac AH, Nubé MJ, Penne EL, Gaillard CA, Wetzels JF, Wiegerinck ET, Swinkels DW, Blankestijn PJ, Ter Wee PM; CONTRAST Investigators. PLoS One 2012;7(7):e39783.
Second round robin for plasma hepcidin methods: first steps toward harmonizationKroot JJ, van Herwaarden AE, Tjalsma H, Jansen RT, Hendriks JC, Swinkels DW. Am J Hematol 2012;87(10):977-83.
Serum hepcidin and macrophage iron correlate with MCP-1 release and vascular damage in patients with metabolic syndrome alterationsValenti L, Dongiovanni P, Motta BM, Swinkels DW, Bonara P, Rametta R, Burdick L, Frugoni C, Fracanzani AL, Fargion S. Arterioscler Thromb Vasc Biol. 2011;31(3):683-90.
Serum ferritin levels are associated with vascular damage in patients with nonalcoholic fatty liver diseaseValenti L, Swinkels DW, Burdick L, Dongiovanni P, Tjalsma H, Motta BM, Bertelli C, Fatta E, Bignamini D, Rametta R, Fargion S, Fracanzani AL. Nutr Metab Cardiovasc Dis. 2011;21(8):568-75.
Mass spectrometry analysis of hepcidin peptides in experimental mouse modelsTjalsma H, Laarakkers CM, van Swelm RP, Theurl M, Theurl I, Kemna EH, van der Burgt YE, Venselaar H, Dutilh BE, Russel FG, Weiss G, Masereeuw R, Fleming RE, Swinkels DW. PLoS One 2011;6(3):e16762.
Hepcidin and hemoglobin content parameters in the diagnosis of iron deficiency in rheumatoid arthritis patients with anemiavan Santen S, van Dongen-Lases EC, de Vegt F, Laarakkers CM, van Riel PL, van Ede AE, Swinkels DW. Arthritis Rheum 2011;63(12):3672-80.
Hepcidin in human iron disorders: diagnostic implicationsKroot JJ, Tjalsma H, Fleming RE, Swinkels DW. Clin Chem 2011;57(12):1650-69.
Iron homeostasis in mother and child during placental malaria infectionVan Santen S, de Mast Q, Luty AJ, Wiegerinck ET, Van der Ven AJ, Swinkels DW. Am J Trop Med Hyg 2011;84(1):148-51.
Inflammation-induced hepcidin-25 is associated with the development of anemia in septic patients: an observational studyvan Eijk LT, Kroot JJ, Tromp M, van der Hoeven JG, Swinkels DW, Pickkers P. Crit Care 2011;15(1):R9.
Hepcidin in malaria superinfection: can findings be translated to humans?van Santen S, de Mast Q, Swinkels DW, van der Ven AJ. Nat Med 2011;17(11):1341.
Determinants of red cell distribution width (RDW) in cardiorenal patients: RDW is not related to erythropoietin resistanceEmans ME, van der Putten K, van Rooijen KL, Kraaijenhagen RJ, Swinkels D, van Solinge WW, Cramer MJ, Doevendans PA, Braam B, Gaillard CA. J Card Fail 2011;17(8):626-33.
Need for early recognition and therapeutic guidelines of congenital sideroblastic anaemiaCuijpers ML, van Spronsen DJ, Muus P, Hamel BC, Swinkels DW. Int J Hematol 2011;94(1):97-100.
Serum hepcidin: reference ranges and biochemical correlates in the general populationGalesloot TE, Vermeulen SH, Geurts-Moespot AJ, Klaver SM, Kroot JJ, van Tienoven D, Wetzels JF, Kiemeney LA, Sweep FC, den Heijer M, Swinkels DW. Blood 2011;117(25):e218-25.
Diagnosis and management of hereditary haemochromatosisvan Bokhoven MA, van Deursen CT, Swinkels DW. BMJ 2011;342:c7251.
Immunochemical and mass-spectrometry-based serum hepcidin assays for iron metabolism disordersKroot JJ, Laarakkers CM, Geurts-Moespot AJ, Grebenchtchikov N, Pickkers P, van Ede AE, Peters HP, van Dongen-Lases E, Wetzels JF, Sweep FC, Tjalsma H, Swinkels DW. Clin Chem 2010;56(10):1570-9.
Hemochromatosis (HFE) genotype and atherosclerosis: Increased susceptibility to iron-induced vascular damage in C282Y carriers?Engberink MF, Povel CM, Durga J, Swinkels DW, de Kort WL, Schouten EG, Verhoef P, Geleijnse JM. Atherosclerosis 2010;211(2):520-5.
Serum hepcidin-25 levels in patients with chronic kidney disease are independent of glomerular filtration ratePeters HP, Laarakkers CM, Swinkels DW, Wetzels JF. Nephrol Dial Transplant 2010;25(3):848-53.
Hepcidin-25 is a marker of the response rather than resistance to exogenous erythropoietin in chronic kidney disease/chronic heart failure patientsvan der Putten K, Jie KE, van den Broek D, Kraaijenhagen RJ, Laarakkers C, Swinkels DW, Braam B, Gaillard CA. Eur J Heart Fail. 2010;12(9):943-50.
Training surface and intensity: inflammation, hemolysis, and hepcidin expressionPeeling P, Dawson B, Goodman C, Landers G, Wiegerinck ET, Swinkels DW, Trinder D. Med Sci Sports Exerc. 2009;41(5):1138-45.
Cumulative effects of consecutive running sessions on hemolysis, inflammation and hepcidin activityPeeling P, Dawson B, Goodman C, Landers G, Wiegerinck ET, Swinkels DW, Trinder D. Eur J Appl Physiol. 2009;106(1):51-9
Effects of exercise on hepcidin response and iron metabolism during recoveryPeeling P, Dawson B, Goodman C, Landers G, Wiegerinck ET, Swinkels DW, Trinder D. Int J Sport Nutr Exerc Metab. 2009;19(6):583-97
Severity of iron overload of proband determines serum ferritin levels in families with HFE-related hemochromatosis: the HEmochromatosis FAmily StudyJacobs EM, Hendriks JC, van Deursen CT, Kreeftenberg HG, de Vries RA, Marx JJ, Stalenhoef AF, Verbeek AL, Swinkels DW. J Hepatol. 2009;50(1):174-83.
A novel immunological assay for hepcidin quantification in human serumKoliaraki V, Marinou M, Vassilakopoulos TP, Vavourakis E, Tsochatzis E, Pangalis GA, Papatheodoridis G, Stamoulakatou A, Swinkels DW, Papanikolaou G, Mamalaki A. PLoS One 2009;4(2):e4581.
High-sensitive radioimmunoassay for human serum hepcidinGrebenchtchikov N, Geurts-Moespot AJ, Kroot JJ, den Heijer M, Tjalsma H, Swinkels DW, Sweep FG. Br J Haematol 2009;146(3):317-25.
Results of the first international round robin for the quantification of urinary and plasma hepcidin assays: need for standardizationKroot JJ, Kemna EH, Bansal SS, Busbridge M, Campostrini N, Girelli D, Hider RC, Koliaraki V, Mamalaki A, Olbina G, Tomosugi N, Tselepis C, Ward DG, Ganz T, Hendriks JC, Swinkels DW. Haematologica 2009;94(12):1748-52.
Assessment of urinary concentrations of hepcidin provides novel insight into disturbances in iron homeostasis during malarial infectionde Mast Q, Nadjm B, Reyburn H, Kemna EH, Amos B, Laarakkers CM, Silalye S, Verhoef H, Sauerwein RW, Swinkels DW, van der Ven AJ. J Infect Dis 2009;199(2):253-62.
Mild increases in serum hepcidin and interleukin-6 concentrations impair iron incorporation in haemoglobin during an experimental human malaria infectionde Mast Q, van Dongen-Lases EC, Swinkels DW, Nieman AE, Roestenberg M, Druilhe P, Arens TA, Luty AJ, Hermsen CC, Sauerwein RW, van der Ven AJ. Br J Haematol 2009;145(5):657-64.
Hepcidin serum levels and resistance to recombinant human erythropoietin therapy in haemodialysis patientsCosta E, Swinkels DW, Laarakkers CM, Rocha-Pereira P, Rocha S, Reis F, Teixeira F, Miranda V, do Sameiro Faria M, Loureiro A, Quintanilha A, Belo L, Santos-Silva A. Acta Haematol 2009;122(4):226-9.
Hereditary haemochromatosisJanssen MC, Swinkels DW. Best Pract Res Clin Gastroenterol 2009;23(2):171-83.
Hepcidin: from discovery to differential diagnosisKemna EH, Tjalsma H, Willems HL, Swinkels DW. Haematologica 2008;93(1):90-7.
Advances in quantitative hepcidin measurements by time-of-flight mass spectrometrySwinkels DW, Girelli D, Laarakkers C, Kroot J, Campostrini N, Kemna EH, Tjalsma H. PLoS One 2008;3(7):e2706.
Serum hepcidin levels are innately low in HFE-related haemochromatosis but differ between C282Y-homozygotes with elevated and normal ferritin levelsvan Dijk BA, Laarakkers CM, Klaver SM, Jacobs EM, van Tits LJ, Janssen MC, Swinkels DW. Br J Haematol 2008;142(6):979-85.
An insight into the relationships between hepcidin, anemia, infections and inflammatory cytokines in pediatric refugees: a cross-sectional studyCherian S, Forbes DA, Cook AG, Sanfilippo FM, Kemna EH, Swinkels DW, Burgner DP. PLoS One 2008;3(12):e4030.
Hepcidin: a new tool in the management of anaemia in patients with chronic kidney disease?Swinkels DW, Wetzels JF. Nephrol Dial Transplant 2008;23(8):2450-3.
A novel (Leu183Pro-)mutation in the HFE-gene co-inherited with the Cys282Tyr mutation in two unrelated Dutch hemochromatosis patientsSwinkels DW, Venselaar H, Wiegerinck ET, Bakker E, Joosten I, Jaspers CA, Vasmel WL, Breuning MH. Blood Cells Mol Dis 2008;40(3):334-8.
Changing aspects of HFE-related hereditary haemochromatosis and endeavours to early diagnosisJacobs EM, Verbeek AL, Kreeftenberg HG, van Deursen CT, Marx JJ, Stalenhoef AF, Swinkels DW, de Vries RA. Neth J Med 2007;65(11):419-24.
Morbidity and mortality in first-degree relatives of C282Y homozygous probands with clinically detected haemochromatosis compared with the general population: the HEmochromatosis FAmily Study (HEFAS)Jacobs EM, Hendriks JC, Marx JJ, van Deursen CT, Kreeftenberg HG, de Vries RA, Stalenhoef AF, Verbeek AL, Swinkels DW. Neth J Med 2007;65(11):425-33.
Nitric oxide does not contribute to inflammation-induced hypoferremia in humansKemna EH, Pickkers P, Tjalsma H, Swinkels DW. Acta Haematol 2007;118(3):149-52.
Effect of the new HJV-L165X mutation on penetrance of HFEvan Dijk BA, Kemna EH, Tjalsma H, Klaver SM, Wiegerinck ET, Goossens JP, Slee PH, Breuning MH, Swinkels DW. Blood 2007;109(12):5525-6.
Non-transferrin-bound iron is associated with plasma level of soluble intercellular adhesion molecule-1 but not with in vivo low-density lipoprotein oxidationvan Tits LJ, Jacobs EM, Swinkels DW, Lemmers HL, van der Vleuten GM, de Graaf J, Stalenhoef AF. Atherosclerosis 2007;194(1):272-8.
Effect of the new HJV-L165X mutation on penetrance of HFEvan Dijk BA, Kemna EH, Tjalsma H, Klaver SM, Wiegerinck ET, Goossens JP, Slee PH, Breuning MH, Swinkels DW. Blood 2007;109(12):5525-6.
Hereditary haemochromatosis: novel genes, novel diseases and hepcidinBergmans JP, Kemna EH, Janssen MC, Jacobs EM, Stalenhoef AF, Marx JJ, Swinkels DW. Ned Tijdschr Geneeskd 2007;151(20):1121-7.
Morbidity and mortality in first-degree relatives of C282Y homozygous probands with clinically detected haemochromatosis compared with the general population: the HEmochromatosis FAmily Study (HEFAS)Jacobs EM, Hendriks JC, Marx JJ, van Deursen CT, Kreeftenberg HG, de Vries RA, Stalenhoef AF, Verbeek AL, Swinkels DW. Neth J Med 2007;65(11):425-33.
Serum non-transferrin-bound iron and low-density lipoprotein oxidation in heterozygous hemochromatosisvan Tits LJ, Jacobs EM, Swinkels DW, Lemmers HL, van der Vleuten GM, de Graaf J, Stalenhoef AF. Biochem Biophys Res Commun 2006;345(1):371-6.
Hereditary hemochromatosis: genetic complexity and new diagnostic approachesSwinkels DW, Janssen MC, Bergmans J, Marx JJ. Clin Chem 2006;52(6):950-68.
Novel urine hepcidin assay by mass spectrometryKemna E, Tjalsma H, Laarakkers C, Nemeth E, Willems H, Swinkels D. Blood 2005;106(9):3268-70.
Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPSKemna E, Pickkers P, Nemeth E, van der Hoeven H, Swinkels D. Blood 2005;106(5):1864-6.
Results of an international round robin for the quantification of serum non-transferrin-bound iron: Need for defining standardization and a clinically relevant isoformJacobs EM, Hendriks JC, van Tits BL, Evans PJ, Breuer W, Liu DY, Jansen EH, Jauhiainen K, Sturm B, Porter JB, Scheiber-Mojdehkar B, von Bonsdorff L, Cabantchik ZI, Hider RC, Swinkels DW. Anal Biochem 2005;341(2):241-50.
Serum ferritin levels are increased in patients with glomerular diseases and proteinuriaBranten AJ, Swinkels DW, Klasen IS, Wetzels JF. Nephrol Dial Transplant 2004;19(11):2754-60.
Diagnosis of 5 patients with possible primary hemochromatosisJacobs EM, de Vries RA, Elving LD, Stalenhoef AF, Swinkels DW. Ned Tijdschr Geneeskd 2003;147(14):666-70.
Rapid genotyping of single nucleotide polymorphisms using novel minor groove binding DNA oligonucleotides (MGB probes)de Kok JB, Wiegerinck ET, Giesendorf BA, Swinkels DW. Hum Mutat 2002;19(5):554-9.
Primary haemochromatosis: a missed cause of chronic fatigue syndrome?Swinkels DW, Aalbers N, Elving LD, Bleijenberg G, Swanink CM, van der Meer JW. Neth J Med 2002;60(11):429-33.
Diagnosis and treatment of primary hemochromatosisSwinkels DW, Marx JJ. Ned Tijdschr Geneeskd 1999;143(27):1404-8.
Hereditary haemochromatosis: recent developments in diagnosticsSwinkels DW, Cooreman MP, van Solinge WW. Ned Tijdschr Geneeskd 1997;141(28):1373-4.